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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-GSK023
GSK023

Chemical Structure : GSK023

CAS No.:

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GSK023 (GSK-023, GSK 023)

货号: PC-21329Not For Human Use, Lab Use Only.

GSK023 is a potent, selective BET BD1 domain inhibitor with pIC50 of 7.8 against BRD4 BD1, >100-fold selective over BD2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GSK023 is a potent, selective BET BD1 domain inhibitor with pIC50 of 7.8 against BRD4 BD1, >100-fold selective over BD2.
GSK023 decreases the levels of MCP-1, IL-8, IL-1, IL-10, M-CSF, and IL-6 in human primary T cells.

物理化学性质&存储条件

分子量 489.66
分子式 C29H39N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-(1-((1-(1-Isopropylpiperidine-4-carbonyl)piperidin-3-yl)methyl)-1H-benzo [d]imidazole-2-yl)-1,3-dimethylpyridin-2(1H)-one

参考文献

1. Bradley E, et al. J Med Chem. 2023 Nov 15. doi: 10.1021/acs.jmedchem.3c00906.

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