GSK-J1 | KDM6A/6B inhibitor | Probechem Biochemicals

Chemical Structure : GSK-J1

CAS No.: 1373422-53-7

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GSK-J1 (KDM6A/6B inhibitor)

货号: PC-38508Not For Human Use, Lab Use Only.

GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively.

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50 mg	￥1480	In stock
100 mg	￥2580	In stock
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生物&药学活性

GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively.
GSK-J1 also inhibits KDM5B, KDM5C and KDM5A (IC50 = 170, 550 and 6,800 nM respectively), exhibits no activity against a panel of other histone demethylases (IC50 >10 uM).

物理化学性质&存储条件

分子量	389.459
分子式	C22H23N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine

参考文献

1. Kruidenier et al. Nature 488 404 PMID: 22842901.

GSK-J1 (KDM6A/6B inhibitor)

生物&药学活性

物理化学性质&存储条件

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GSK-J1 (KDM6A/6B inhibitor)

生物&药学活性

物理化学性质&存储条件

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