GSK-F1

Chemical Structure : GSK-F1

CAS No.: 1402345-92-9

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货号: PC-26709Not For Human Use, Lab Use Only.

GSK-F1 is a potent, selective phosphatidylinositol 4-kinase type IIIα (PI4KA) inhibitor with pIC50 of 8.0, also directly binds to NSUN2 and promote its proteasomal degradation.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

GSK-F1 is a potent, selective phosphatidylinositol 4-kinase type IIIα (PI4KA) inhibitor with pIC50 of 8.0, also directly binds to NSUN2 and promote its proteasomal degradation.
GSK-F1shows selectivity over PI4KB, PI3KA, PI3KB, PI3KG and PI3KD.
GSK-F1 activates the downstream TP53/RAD51 signaling axis and increasing NPC cell cytotoxicity and radiosensitivity.

物理化学性质&存储条件

分子量	603.52
分子式	C27H18F5N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

参考文献

1. Bojjireddy N, et al. J Biol Chem. 2014 Feb 28;289(9):6120-32.

2. Lemei Zheng, et al. Int J Biol Sci. 2026 Mar 30;22(8):4043-4058.

GSK-F1

生物&药学活性

物理化学性质&存储条件

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GSK-F1

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物理化学性质&存储条件

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