GSK-8999 |CAS:1422355-59-6 Probechem Biochemicals

Chemical Structure : GSK-8999

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GSK-8999 (GSK-2578999, GSK8999)

货号: PC-62831Not For Human Use, Lab Use Only.

GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively.

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生物&药学活性

GSK-8999 (GSK-2578999) is a novel, potent HIV-1 maturation inhibitor with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively.
GSK-8999 shows high potency against 57 of 62 isolates demonstrating an improvement over the first generation maturation inhibitor BVM.
GSK-8999 has a mechanism of action consistent with inhibition of the proteolytic cleavage of CA-SP1.

物理化学性质&存储条件

分子量	776.44
分子式	C46H62ClNO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3β)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-N-[1-(4-chlorophenyl)cyclopropyl]-α,21-dioxo-28-norlup-18-ene-17-acetamide

参考文献

1. Tang J, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2689-2694.

GSK-8999 (GSK-2578999, GSK8999)

生物&药学活性

物理化学性质&存储条件

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GSK-8999 (GSK-2578999, GSK8999)

生物&药学活性

物理化学性质&存储条件

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