GSK-7975A |CAS:1253186-56-9 Probechem Biochemicals

Chemical Structure : GSK-7975A

CAS No.: 1253186-56-9

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GSK-7975A (GSK-7975;GSK7975)

货号: PC-70096Not For Human Use, Lab Use Only.

GSK-7975A (GSK7975A) is a selective CRAC channel blocker that inhibits store-operated Ca(2+) entry (SOCE) with IC50 of 3.4 uM.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

GSK-7975A (GSK7975A) is a selective CRAC channel blocker that inhibits store-operated Ca(2+) entry (SOCE) with IC50 of 3.4 uM.
GSK-7975A shows little or no effect on the physiological Ca(2+) spiking evoked by acetylcholine or cholecystokinin.
GSK-7975A inhibits the release of mast cell mediators and T-cell cytokines from multiple human and rat preparations.

物理化学性质&存储条件

分子量	397.305
分子式	C18H12F5N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide

参考文献

1. Gerasimenko JV, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13186-91.

2. Rice LV, et al. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.

3. Derler I, et al. Cell Calcium. 2013 Feb;53(2):139-51.

GSK-7975A (GSK-7975;GSK7975)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK-7975A (GSK-7975;GSK7975)

生物&药学活性

物理化学性质&存储条件

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