GSK-690693 |CAS:937174-76-0 Probechem Biochemicals

Chemical Structure : GSK-690693

CAS No.: 937174-76-0

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GSK-690693 (GSK 690693;GSK690693)

货号: PC-42484Not For Human Use, Lab Use Only.

GSK-690693 (GSK690693) is a potent, ATP competitive, pan-AKT inhibitor with IC50 of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

GSK-690693 (GSK690693) is a potent, ATP competitive, pan-AKT inhibitor with IC50 of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.
GSK-690693 (GSK690693) also inhibits additional members of the AGC kinase family (PKA, PrkX, and PKC isozymes, IC50s<100 nM).
GSK-690693 (GSK690693) dose-dependently reduces the phosphorylation GSK3 beta, PRAS40 and Forkhead, inhibits proliferation and induces apoptosis in a subset of tumor cells.
GSK-690693 (GSK690693) exhibits significant antitumor activity in mice model.

物理化学性质&存储条件

分子量	425.4842
分子式	C21H27N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Butyn-2-ol, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-

参考文献

1. Heerding DA, et al. J Med Chem. 2008 Sep 25;51(18):5663-79.

2. Rhodes N, et al. Cancer Res. 2008 Apr 1;68(7):2366-74.

3. Levy DS, et al. Blood. 2009 Feb 19;113(8):1723-9.

GSK-690693 (GSK 690693;GSK690693)

生物&药学活性

物理化学性质&存储条件

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GSK-690693 (GSK 690693;GSK690693)

生物&药学活性

物理化学性质&存储条件

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