GSK-588045 | 5-HT1A/B/D antagonist | Probechem Biochemicals

Chemical Structure : GSK-588045

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GSK-588045 (GSK588045, GSK 588045)

货号: PC-61583Not For Human Use, Lab Use Only.

GSK-588045 is a potent and selective 5-HT1A/B/D receptor antagonist with Ki of 9.5/8.8/9.8, respectively.

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生物&药学活性

GSK-588045 is a potent and selective 5-HT1A/B/D receptor antagonist with Ki of 9.5/8.8/9.8, respectively.
GSK-588045 exhibits high selectivity over human hERG potassium channels, favorable pharmacokinetics, and excellent activity in vivo in rodent pharmacodynamic (PD) models.
GSK-588045 demonstrates potential as a faster acting antidepressant/anxiolytic with reduced side-effect burden.

物理化学性质&存储条件

分子量	468.561
分子式	C27H28N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide

参考文献

1. Bromidge SM, et al. J Med Chem. 2010 Aug 12;53(15):5827-43.

2. Comley RA, et al. Neuropharmacology. 2015 May;92:44-8.

GSK-588045 (GSK588045, GSK 588045)

生物&药学活性

物理化学性质&存储条件

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GSK-588045 (GSK588045, GSK 588045)

生物&药学活性

物理化学性质&存储条件

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