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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-CRAC Channel-GSK-5498A
GSK-5498A

Chemical Structure : GSK-5498A

CAS No.: 1253186-49-0

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GSK-5498A (GSK5498A)

货号: PC-43089Not For Human Use, Lab Use Only.

GSK-5498A is a potent, selective small molecule blocker of Calcium-Release Activated Calcium (CRAC) channel with IC50 of 1 uM.

规格 价格 库存 数量
5 mg ￥2880 In stock
10 mg ￥4280 In stock
25 mg ￥7280 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK-5498A is a potent, selective small molecule blocker of Calcium-Release Activated Calcium (CRAC) channel with IC50 of 1 uM.
GSK-5498A completely inhibits calcium influx through CRAC channels.
GSK-5498A inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells from multiple human and rat preparations.

物理化学性质&存储条件

分子量 399.2899
分子式 C18H11F6N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 2,6-difluoro-N-[1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-3-yl]-

参考文献

1. Rice LV, et al. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.

2. Chen J, et al. J Physiol. 2017 May 15;595(10):3203-3218.

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