GSK-3β inhibitor G3I

Chemical Structure : GSK-3β inhibitor G3I

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货号: PC-25343Not For Human Use, Lab Use Only.

GSK-3β inhibitor G3I is a specific GSK-3β inhibitor, inhibits nitric oxide (NO) production in LPS-stimulated macrophages with IC50 of 3.65 uM.

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250 mg		Get quote

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生物&药学活性

GSK-3β inhibitor G3I is a specific GSK-3β inhibitor, inhibits nitric oxide (NO) production in LPS-stimulated macrophages with IC50 of 3.65 uM.
G3I reduces total phosphorylation in macrophages and decreases the production of pro-inflammatory cytokines in LPS-stimulated macrophages.
G3I decreases the phosphorylation of NF-κB transcription factor acting as anti-inflammatory reagent。
G3I regulates macrophage polarization, markedly suppresses the expression of Arginase-1 (Arg-1), CD206, and CCL18, indicative of M2-like phenotype inhibition.
G3I improves the tumor cell cytotoxicity and phagocytosis efficacy of M1-like macrophages and reinforces tumoricidal activity in in vivo mouse model.
G3I enhances the tumoricidal activity of macrophages in vivo.

物理化学性质&存储条件

分子量	372.40
分子式	C22H17FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N-(pyridin-4-ylmethyl)acrylamide

参考文献

1. Lee C, et al. Biomed Pharmacother. 2025 Aug 11;191:118448.