GSK-2878175 |CAS:1423007-82-2 Probechem Biochemicals

Chemical Structure : GSK-2878175

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GSK-2878175 (GSK2878175;GSK8175;GSK-175;GSK-175A)

货号: PC-63383Not For Human Use, Lab Use Only.

GSK-2878175 (GSK8175, GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B palm polymerase inhibitor with EC50 of 0.4-9.7 nM.

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1 g		Get quote

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生物&药学活性

GSK-2878175 (GSK8175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM
GSK-2878175 exhibited low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons.
GSK-2878175 displayed a 60-63 h half-life and a robust decrease in viral RNA levels in HCV infected patients relative to GSK5852.

物理化学性质&存储条件

分子量	568.807
分子式	C27H23BClFN2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[N-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

参考文献

1. Gardner SD, et al. J Viral Hepat. 2018 Jan;25(1):19-27.

2. Chong PY, et al. J Med Chem. 2019 Feb 14. doi: 10.1021/acs.jmedchem.8b01719.

GSK-2878175 (GSK2878175;GSK8175;GSK-175;GSK-175A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK-2878175 (GSK2878175;GSK8175;GSK-175;GSK-175A)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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