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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-GSK-2807
GSK-2807

Chemical Structure : GSK-2807

CAS No.: N/A

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GSK-2807 (GSK 2807;GSK2807)

货号: PC-70109Not For Human Use, Lab Use Only.

GSK-2807 (GSK 2807, GSK2807) is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki of 14 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GSK-2807 (GSK 2807, GSK2807) is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki of 14 nM; displays 24-fold selectivity over SMYD2, and a panel of PRMTs including: PRMT1, PRMT4, PRMT5, NSD2, NSD3, DOT1L, G9a, and ASH1L.

物理化学性质&存储条件

分子量 452.516
分子式 C19H32N8O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(dimethylamino)propyl)amino)butanoic acid

参考文献

1. Van Aller GS, et al. Structure. 2016 May 3;24(5):774-81.

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