GSK-2485852 |CAS:1331942-30-3 Probechem Biochemicals

Chemical Structure : GSK-2485852

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GSK-2485852 (GSK2485852;GSK 2485852;GSK-5852;GSK 5852;GSK5852)

货号: PC-60428Not For Human Use, Lab Use Only.

GSK-2485852 (GSK2485852, GSK5852) is a highly potent, selective HCV NS5B polymerase inhibitor with IC50 of 3.0 and 1.6 nM for HCV genotypes 1a and 1b in replicon assay, respectively.

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生物&药学活性

GSK-2485852 (GSK2485852, GSK5852) is a highly potent, selective HCV NS5B polymerase inhibitor with IC50 of 3.0 and 1.6 nM for HCV genotypes 1a and 1b in replicon assay, respectively.
GSK-2485852 displays an excellent resistance profile and shows a <5-fold potency loss across the clinically important NS5B resistance mutations P495L, M423T, C316Y, and Y448H; targets NNI palm site 2 of NS5B and inhibits all HCV genotypes.

物理化学性质&存储条件

分子量	554.3718
分子式	C27H25BF2N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	B-[4-[[[5-Cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-6-benzofuranyl](methylsulfonyl)amino]methyl]-2-fluorophenyl]boronic acid

参考文献

1. Voitenleitner C, et al. Antimicrob Agents Chemother. 2013 Nov;57(11):5216-24.

2. Wilfret DA, et al. Clin Pharmacol Drug Dev. 2014 Nov;3(6):439-48.

3, Chong PY, et al. J Med Chem. 2019 Feb 14. doi: 10.1021/acs.jmedchem.8b01719.

GSK-2485852 (GSK2485852;GSK 2485852;GSK-5852;GSK 5852;GSK5852)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK-2485852 (GSK2485852;GSK 2485852;GSK-5852;GSK 5852;GSK5852)

生物&药学活性

物理化学性质&存储条件

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