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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-GSK-2336805
GSK-2336805

Chemical Structure : GSK-2336805

CAS No.: 1256390-53-0

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GSK-2336805 (JNJ-56914845, GSK2336805, JNJ56914845)

货号: PC-63396Not For Human Use, Lab Use Only.

GSK-2336805 (JNJ-56914845) is a novel potent HCV NS5A inhibitor with multigenotype activity, has EC50s of 58.5, 7.4, and 53.8 pM on genotype 1a (H77), genotype 1b (Con-1 ET), and genotype 2a (JFH-1) replicon cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GSK-2336805 (JNJ-56914845) is a novel potent HCV NS5A inhibitor with multigenotype activity, has EC50s of 58.5, 7.4, and 53.8 pM on genotype 1a (H77), genotype 1b (Con-1 ET), and genotype 2a (JFH-1) replicon cells.
    GSK-2336805 shows an average EC50 of 63.7 pM on genotype 2a Jc1 virus, inhibits the HCV replication cycle and production of virus.
    GSK-2336805 retains activity on chimeric replicons containing NS5A patient sequences from genotype 1 and patient and consensus sequences for genotypes 4 and 5 and part of genotype 6.

    物理化学性质&存储条件

    分子量 796.926
    分子式 C42H52N8O8
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl ((S)-1-((S)-8-(4-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-1,4-dioxa-7-azaspiro[4.4]nonan-7-yl)-3-methyl-1-oxobutan-2-yl)carbamate

    参考文献

    1. Walker J, et al. Antimicrob Agents Chemother. 2014;58(1):38-47.

    2. Kazmierski WM, et al. J Med Chem. 2014 Mar 13;57(5):2058-73.

    3. Bourgeois S, et al. BMC Gastroenterol. 2017 Feb 10;17(1):26.

    4. Wilfret DA, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):5037-44.

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