GSK-229423 |CAS:1352149-24-6 Probechem Biochemicals

Chemical Structure : GSK-229423

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GSK-229423 (GSK229423)

货号: PC-61940Not For Human Use, Lab Use Only.

GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.

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生物&药学活性

GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM.
GSK-229423 displays approximately 70 times more potent against S. aureus DNA gyrase than NXL101.
GSK-229423 has potent antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacterial pathogens, including clinical isolates with fluoroquinolone resistance mediated by DNA gyrase and topo IV mutations.

物理化学性质&存储条件

分子量	459.612
分子式	C26H29N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-(([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-6-ethylquinoline-3-carbonitrile

参考文献

1. Bax BD, et al. Nature. 2010 Aug 19;466(7309):935-40.

GSK-229423 (GSK229423)

生物&药学活性

物理化学性质&存储条件

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GSK-229423 (GSK229423)

生物&药学活性

物理化学性质&存储条件

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