GSK-2292767 |CAS:1254036-66-2 Probechem Biochemicals

Chemical Structure : GSK-2292767

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GSK-2292767 (GSK2292767)

货号: PC-70090Not For Human Use, Lab Use Only.

GSK-2292767 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1).

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1 g		Get quote

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生物&药学活性

GSK-2292767 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1).
GSK-2292767 displays >1,000 fold selectivity versus others PI3K isoforms.
GSK-2292767 inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.7 and 8.5, respectively, in a human lung parenchyma assay.
GSK-2292767 shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=35 ug/kg).

物理化学性质&存储条件

分子量	512.58
分子式	C24H28N6O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(4-(5-(((2R,6S)-2,6-dimethylmorpholino)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxypyridin-3-yl)methanesulfonamide

参考文献

1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.

GSK-2292767 (GSK2292767)

生物&药学活性

物理化学性质&存储条件

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GSK-2292767 (GSK2292767)

生物&药学活性

物理化学性质&存储条件

参考文献

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