GSK-2269557 |CAS:1254036-71-9 Probechem Biochemicals

Chemical Structure : GSK-2269557

CAS No.: 1254036-71-9

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GSK-2269557 (GSK2269557;Nemiralisib)

货号: PC-45643Not For Human Use, Lab Use Only.

Nemiralisib (GSK-2269557) is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4380	In stock
100 mg		Get quote

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生物&药学活性

Nemiralisib (GSK-2269557) is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).
Nemiralisib (GSK-2269557) displays >1000 fold selectivity versus other PI3K isoforms.
Nemiralisib (GSK-2269557) inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.2 and 8.1, respectively, in a human lung parenchyma assay.
Nemiralisib (GSK-2269557) shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=67ug/kg).

物理化学性质&存储条件

分子量	440.5401
分子式	C26H28N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-

参考文献

1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.

GSK-2269557 (GSK2269557;Nemiralisib)

生物&药学活性

物理化学性质&存储条件

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GSK-2269557 (GSK2269557;Nemiralisib)

生物&药学活性

物理化学性质&存储条件

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