GSK-1 |CAS:912953-25-4 Probechem Biochemicals

Chemical Structure : GSK-1

CAS No.: 912953-25-4

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GSK-1 (Eg5 Inhibitor VII, GSK1)

货号: PC-62336Not For Human Use, Lab Use Only.

GSK-1 is an ATP-competitive inhibitor of the mitotic kinesin KSP with HCT116 cell IC50 of 36 nM.

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生物&药学活性

GSK-1 is an ATP-competitive inhibitor of the mitotic kinesin KSP with HCT116 cell IC50 of 36 nM.
GSK-1 induces monopolar spindle formation in SKOV3 cells, and shows markedly greater potency (IC50 of 0.5 nM) in the ispinesib-resistant HCT116-D130V cell line.

物理化学性质&存储条件

分子量	291.273
分子式	C16H12F3NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinolin-2(1H)-one

参考文献

1. Luo L, et al. Nat Chem Biol. 2007 Nov;3(11):722-6.

GSK-1 (Eg5 Inhibitor VII, GSK1)

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物理化学性质&存储条件

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GSK-1 (Eg5 Inhibitor VII, GSK1)

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物理化学性质&存储条件

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