GSDMD agonist DMB | Gasdermin D agonist | Probechem Biochemicals

Chemical Structure : GSDMD agonist DMB

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GSDMD agonist DMB (Compound C-185)

货号: PC-23025Not For Human Use, Lab Use Only.

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生物&药学活性

GSDMD agonist DMB is a direct and selective gasdermin D (GSDMD) agonist, activates GSDMD pore formation to trigger liposome leakage with EC50 of 0.7 uM, activates GSDMD pore formation and pyroptosis without cleaving GSDMD.
DMB directly binds to GSDMD by microscale thermophoresis (MST) with a dissociation constant (KD) of 1.1 uM.
DMB induces pyroptosis in immortalized and primary cells in a GSDMD-dependent and cleavage-independent manner.
DMB binds to GSDMD and induces cleavage-independent GSDMD oligomerization and pore formation. activated human GSDMD but not other human gasdermins, also activates mouse GSDMD in the liposome leakage assay, albeit with ∼5-fold reduced efficacy.
GSDMD agonist DMB modifies GSDMD at C191, which is conserved in GSDMD from different species but not in other gasdermin family members.
DMB induces tumor regression and enhances antitumor immunity that depends on GSDMD expression in the tumor.

物理化学性质&存储条件

分子量	348.24
分子式	C13H15Cl2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(tert-butyl)-6,7-dichloro-3-(methylsulfonyl)quinoxalin-2-amine

参考文献

1. Fontana P, Cell. 2024 Sep 2:S0092-8674(24)00898-5.

GSDMD agonist DMB (Compound C-185)

生物&药学活性

物理化学性质&存储条件

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GSDMD agonist DMB (Compound C-185)

生物&药学活性

物理化学性质&存储条件

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