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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Smoothened (Smo)-GSA-10
GSA-10

Chemical Structure : GSA-10

CAS No.: 300833-95-8

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GSA-10 (GSA10)

货号: PC-62172Not For Human Use, Lab Use Only.

GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay.

规格 价格 库存 数量
5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay.
GSA-10 promotes the differentiation of multipotent mesenchymal progenitor cells into osteoblasts, this effect on cell differentiation is inhibited by Smo antagonists, such as MRT-83, SANT-1, LDE225, and M25 in the nanomolar range.
GSA-10 binds to a novel Smo active site, and belongs to a new class of Smo agonists.

物理化学性质&存储条件

分子量 450.535
分子式 C26H30N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester

参考文献

1. Gorojankina T, et al. Mol Pharmacol. 2013 May;83(5):1020-9.

2. Fleury A, et al. Sci Rep. 2016 Mar 24;6:23479.

3. Manetti F, et al. Eur J Med Chem. 2016 Oct 4;121:747-57.

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