GS-626510 |CAS:1637770-13-8 Probechem Biochemicals

Chemical Structure : GS-626510

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GS-626510 (GS-6510;GS 6510;GS 626510)

货号: PC-70222Not For Human Use, Lab Use Only.

GS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT.

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生物&药学活性

GS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT; shows weak affinity for CREBBP and EP300 (Ki=170 and 220 nM); potently inhibits growth of RKO cells with IC50 of 33 nM, decreases MYC levels; TRIM33 is required for the ability of GS-626510 to maximally down-regulate MYC.

物理化学性质&存储条件

分子量	394.478
分子式	C25H22N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-5-yl)-3,5-dimethylisoxazole

参考文献

1. Shi X, et al. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.

GS-626510 (GS-6510;GS 6510;GS 626510)

生物&药学活性

物理化学性质&存储条件

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GS-626510 (GS-6510;GS 6510;GS 626510)

生物&药学活性

物理化学性质&存储条件

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