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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Filovirus-GS-5734
GS-5734

Chemical Structure : GS-5734

CAS No.: 1809249-37-3

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GS-5734 (GS 5734, GS5734, Remdesivir)

货号: PC-60313Not For Human Use, Lab Use Only.

GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays.

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生物&药学活性

GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays.
GS-5734 (Remdesivir) suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.
GS-5734 (Remdesivir) is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

物理化学性质&存储条件

分子量 601.597
分子式 C28H36N5O8P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-b]pyridazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

参考文献

1. Warren TK, et al. Nature. 2016 Mar 17;531(7594):381-5.

2. Jacobs M, et al. Lancet. 2016 Jul 30;388(10043):498-503.

3. Siegel D, et al. J Med Chem. 2017 Mar 9;60(5):1648-1661.

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