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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-GS-441524
GS-441524

Chemical Structure : GS-441524

CAS No.: 1191237-69-0

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GS-441524 (GS441524)

货号: PC-21077Not For Human Use, Lab Use Only.

GS-441524 (GS441524) is the active metabolite of Remdesivir, inhibits viral RNA dependent RNA polymerase (RdRp) from the Flaviviridae family.

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100 mg ￥880 In stock
200 mg ￥1280 In stock
500 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GS-441524 (GS441524) is the active metabolite of Remdesivir, inhibits viral RNA dependent RNA polymerase (RdRp) from the Flaviviridae family.
GS-441524 effectively inhibits FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM.

物理化学性质&存储条件

分子量 291.27
分子式 C12H13N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

参考文献

1. Murphy BG, et al. Vet Microbiol. 2018 Jun;219:226-233.

2. Shannon A, et al. Antiviral Res. 2020 Jun;178:104793.

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