GRP-60367 | RABV entry inhibitor | Probechem Biochemicals

Chemical Structure : GRP-60367

CAS No.: 1309241-34-6

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GRP-60367 (GRP60367)

货号: PC-72433Not For Human Use, Lab Use Only.

GRP-60367 (GRP60367) is a first-in-class, potent and specific, direct-acting rabies virus (RABV) inhibitor with EC50 of 2-52 nM on different host cell lines, inhibits entry of a subset of RABV strains.

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生物&药学活性

GRP-60367 (GRP60367) is a first-in-class, potent and specific, direct-acting rabies virus (RABV) inhibitor with EC50 of 2-52 nM on different host cell lines, inhibits entry of a subset of RABV strains.
GRP-60367 did not detect morphological signs of cytotoxicity or altered cell metabolic activity after prolonged 48-h exposure of cells to up to 300 uM.
GRP-60367 shows inhibitory activity against fully replication-competent RABV-SAD-B19 (EC50=0.27 uM), rRABV-CVS-N2c is approximately 10-fold less sensitive (EC50=2.63 uM) and the bat isolate is unsensitive (10 uM highest).
GRP-60367 efficiently inhibited the chimeric recVSV-ΔG-eGFP-GRABV virus (EC50=5 nM).
GRP-60367 blocks RABV G protein-mediated viral entry.

物理化学性质&存储条件

分子量	353.466
分子式	C21H27N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-((2-(2,5-dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone

参考文献

1. Venice Du Pont, et al. J Virol. 2020 Jun 16;94(13):e00321-20.

GRP-60367 (GRP60367)

生物&药学活性

物理化学性质&存储条件

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GRP-60367 (GRP60367)

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