GRN-529 | mGluR5 NAM | Probechem Biochemicals

Chemical Structure : GRN-529

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GRN-529 (GRN 529, GRN529)

货号: PC-61060Not For Human Use, Lab Use Only.

GRN-529 is a highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM.

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生物&药学活性

GRN-529 is a highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM.
GRN-529 displays >1,000-fold selective vs mGluR1.
GRN-529 reduces repetitive behaviors and rescues social deficits in mouse models of autism, demonstrates dose-dependent efficacy across a therapeutically relevant battery of animal models, comprising depression, anxiety and pain, with no effect on rat sexual behavior or motor co-ordination.

物理化学性质&存储条件

分子量	391.378
分子式	C22H15F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl)(5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)methanone

参考文献

1. Silverman JL, et al. Sci Transl Med. 2012 Apr 25;4(131):131ra51.

2. Hughes ZA, et al. Neuropharmacology. 2013 Mar;66:202-14.

3. Harvey BD, et al. Neuropharmacology. 2013 Dec;75:19-30.

GRN-529 (GRN 529, GRN529)

生物&药学活性

物理化学性质&存储条件

参考文献

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GRN-529 (GRN 529, GRN529)

生物&药学活性

物理化学性质&存储条件

参考文献

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