GRL018-21 | GRK5 inhibitor | Probechem Biochemicals

Chemical Structure : GRL018-21

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GRL018-21 (GRL 018-21)

货号: PC-21461Not For Human Use, Lab Use Only.

GRL018-21 is a highly selective, potent, and non-covalent GRK5 inhibitor with IC50 of 10 nM, >100,000-fold selectivity over GRK2.

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生物&药学活性

GRL018-21 is a highly selective, potent, and non-covalent GRK5 inhibitor with IC50 of 10 nM, >100,000-fold selectivity over GRK2.
GRL018-21 forms a hemithioketal intermediate with active site Cys474 in the GRK5 active site.

物理化学性质&存储条件

分子量	526.52
分子式	C29H23FN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,Z)-N-(1-(4-fluorophenyl)ethyl)-3-((4-(2-(furan-2-yl)-2-oxoacetamido)-3-methyl-1H-pyrrol-2-yl)methylene)-2-oxoindoline-5-carboxamide

参考文献

1. Yueyi Chen, et al. Eur J Med Chem. 2023 Nov 10:264:115931.

GRL018-21 (GRL 018-21)

生物&药学活性

物理化学性质&存储条件

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GRL018-21 (GRL 018-21)

生物&药学活性

物理化学性质&存储条件

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