GRL-0617 |CAS:1093070-16-6 Probechem Biochemicals

Chemical Structure : GRL-0617

CAS No.: 1093070-16-6

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GRL-0617 (GRL0617;GRL 0617)

货号: PC-70199Not For Human Use, Lab Use Only.

GRL-0617 (GRL0617) is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2380	In stock
50 mg	￥3880	In stock
100 mg		Get quote

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生物&药学活性

GRL-0617 (GRL0617) is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM.
GRL-0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 14.5 uM, has no associated cytotoxicity and no inhibition for host DUBs (human deubiquitinating enzymes HAUSP, USP18, UCH-L1, UCH-L3).

物理化学性质&存储条件

分子量	304.393
分子式	C20H20N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide

参考文献

1. Ratia K, et al. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.

2. Chaudhuri R, et al. J Mol Biol. 2011 Nov 25;414(2):272-88.

GRL-0617 (GRL0617;GRL 0617)

生物&药学活性

物理化学性质&存储条件

参考文献

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GRL-0617 (GRL0617;GRL 0617)

生物&药学活性

物理化学性质&存储条件

参考文献

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