GRK6 inhibitor 18

Chemical Structure : GRK6 inhibitor 18

CAS No.: 2677786-61-5

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货号: PC-72421Not For Human Use, Lab Use Only.

GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM.
GRK6 inhibitor 18 displays >1,000-fold selectivity over Aurora A, as well as high selectivity against a panel of 85 kinases.
GRK6 inhibitor 18 has potent cellular target engagement and antiproliferative activity against MM cells (IC50=0.4-0.46 uM) and is synergistic with bortezomib.

物理化学性质&存储条件

分子量	438.916
分子式	C22H23ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility
Chemical Name/SMILES	N2-(4-chloro-2-methoxybenzyl)-N4-(5-ethyl-1H-pyrazol-3-yl)-5-methoxyquinazoline-2,4-diamine

参考文献

1. David E Uehling, et al. J Med Chem. 2021 Aug 12;64(15):11129-11147.