GRK5-IN-2 | GRK5 inhibitor | Probechem Biochemicals

Chemical Structure : GRK5-IN-2

CAS No.: 1642839-27-7

加入收藏

GRK5-IN-2 (Compound 707)

货号: PC-23911Not For Human Use, Lab Use Only.

GRK5-IN-2 (Compound 707)is a potent, selective G-protein-coupled receptor kinase 5 (GRK5) inhibitor with IC50 of 49.7 uM in luminescent ADP detection assay.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GRK5-IN-2 (Compound 707)is a potent, selective G-protein-coupled receptor kinase 5 (GRK5) inhibitor with IC50 of 49.7 uM in luminescent ADP detection assay.
GRK5-IN-2 treatment significantly decreased TAG synthesis during 7 days of WT 3T3-L1 adipocyte differentiation in a dose-dependent manner.
GRK5-IN-2 inhibitor treatment significantly decreased the rate of TAG, cholesteryl ester (CE), and phospholipid (PL), but not free cholesterol (FC), synthesis from [14C]-acetic acid in WT 3T3-L1 adipocyte.

物理化学性质&存储条件

分子量	380.40
分子式	C20H20N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Imidazo[4,5-c]pyridin-6-amine, 2-(2-furanyl)-1-methyl-N-(3,4,5-trimethoxyphenyl)-

参考文献

1. Axel Ullrich, et al. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators. EP2818472A1.

2. Seramur ME, et al. Int J Obes (Lond). 2025 Jan 21. doi: 10.1038/s41366-025-01712-w.

GRK5-IN-2 (Compound 707)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GRK5-IN-2 (Compound 707)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.