GRK2-IN-115h hydrochloride |CAS:1941168-71-3 Probechem Biochemicals

Chemical Structure : GRK2-IN-115h hydrochloride

加入收藏

GRK2-IN-115h hydrochloride (GRK2 inhibitor 115h hydrochloride)

货号: PC-60353Not For Human Use, Lab Use Only.

GRK2-IN-115h hydrochloride is a highly potent and selective GRK2 inhibitor with IC50 of 18 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GRK2-IN-115h hydrochloride is a highly potent and selective GRK2 inhibitor with IC50 of 18 nM.
GRK2-IN-115h shows enough selectivity against GRK1/5/6/7, ROCK2 and PKCα with equipotent inhibition to GRK3 (IC50=5.4 nM).
GRK2-IN-115h potentiates βAR-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol.
GRK2-IN-115h is a novel potential agent for heart failure treatment.

物理化学性质&存储条件

分子量	502.926
分子式	C24H22ClF3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(((4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)methyl)amino)-N-(2-(trifluoromethyl)benzyl)benzamide hydrochloride

参考文献

1. Okawa T, et al. J Med Chem. 2017 Aug 24;60(16):6942-6990.

GRK2-IN-115h hydrochloride (GRK2 inhibitor 115h hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GRK2-IN-115h hydrochloride (GRK2 inhibitor 115h hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.