GRC-17536 | TRPA1 inhibitor | Probechem Biochemicals

Chemical Structure : GRC-17536

CAS No.: 1246761-03-4

加入收藏

GRC-17536 (GRC 17536)

货号: PC-49700Not For Human Use, Lab Use Only.

GRC-17536 (GRC 17536) is a potent and selective TRPA1 antagonist, inhibits citric acid -induced Ca+2 influx with IC50 of 8.2 nM in cell-based assays.

规格	价格	库存
5 mg	￥2980	In stock
10 mg	￥4780	In stock
25 mg	￥7980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GRC-17536 (GRC 17536) is a potent and selective TRPA1 antagonist, inhibits citric acid -induced Ca+2 influx with IC50 of 8.2 nM in cell-based assays.
GRC-17536 displays no significant activity against TRPV1, TRPV3, TRPV4, TRPM8 at 1 uM.
GRC 17536 (10 nM and 1 µM) inhibited LPS + AITC, Loxoribine + AITC and ssRNA40 + AITC induced 45Ca+2 uptake by 51.3% & 98.4%, 56.6% & 98.6% and 63.0% & 96.1% respectively in hTRPA1/CHO cells.
GRC 17536 blocked citric acid mediated cough in Guinea pigs, showed 79 and 89% inhibition of cough at 60 and 100 mg/kg respectively compared to the vehicle treated animal group.

物理化学性质&存储条件

分子量	516.46
分子式	C20H13F5N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2,4-difluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

参考文献

1. Mukhopadhyay I, et al. PLoS One. 2014 May 12;9(5):e97005.

2. Khairatkar J. N.et al. TRPA1 Antagonist for the Treatment of Pain Associated to Diabetic Neuropathic Pain. WO2016042501 A1, 2016.

GRC-17536 (GRC 17536)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GRC-17536 (GRC 17536)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.