GR127935 |CAS:148672-13-3 Probechem Biochemicals

Chemical Structure : GR127935

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GR127935 (GR-127935)

货号: PC-61865Not For Human Use, Lab Use Only.

GR127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.

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生物&药学活性

GR127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.
GR127935 displays >100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types.
GR127935 blocks porcine carotid vascular response to sumatriptan in vivo; orally bioavailable and centrally active.

物理化学性质&存储条件

分子量	497.587
分子式	C29H31N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide

参考文献

1. Clitherow JW, et al. J Med Chem. 1994 Jul 22;37(15):2253-7.

2. Knobelman DA, et al. J Pharmacol Exp Ther. 2001 Sep;298(3):1083-91.

3. De Vries P, et al. Br J Pharmacol. 1996 May;118(1):85-92.

GR127935 (GR-127935)

生物&药学活性

物理化学性质&存储条件

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GR127935 (GR-127935)

生物&药学活性

物理化学性质&存储条件

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