GQ352 | Gαq/11 inhibitor | Probechem Biochemicals

Chemical Structure : GQ352

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GQ352 (GQ-352)

货号: PC-47039Not For Human Use, Lab Use Only.

GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.

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生物&药学活性

GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM.
GQ352 inhibits uveal melanoma (UM) tumorigenesis by suppressing Gαq/11 downstream ERK phosphorylation and YAP dephosphorylation.

物理化学性质&存储条件

分子量	462.682
分子式	C29H42N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-2-amino-1-((S)-8-(cyclohexylmethyl)-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-3-methylpentan-1-one

参考文献

1. Jun-Jie Deng, et al. Eur J Med Chem. 2022 Jun 11;239:114520.

GQ352 (GQ-352)

生物&药学活性

物理化学性质&存储条件

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GQ352 (GQ-352)

生物&药学活性

物理化学性质&存储条件

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