GQ262 | Gαq/11 inhibitor | Probechem Biochemicals

Chemical Structure : GQ262

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GQ262 (GQ-262)

货号: PC-23378Not For Human Use, Lab Use Only.

GQ262 is a small molecule Gαq/11 protein inhibitor with IC50 of <10 uM, inhibits MP41 cell proliferation with IC50 of 5.1 uM.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

GQ262 is a small molecule Gαq/11 protein inhibitor with IC50 of <10 uM, inhibits MP41 cell proliferation with IC50 of 5.1 uM.
GQ262 efficiently blocked UM cell proliferation and migration in vitro. Analysis of the apoptosis-related proteins, extracellular signal-regulated kinase (ERK), and yes-associated protein (YAP).
GQ262 distinctly induced UM cells apoptosis and disrupted the downstream effectors by targeting Gαq/11 directly.
GQ262 showed outstanding antitumor efficacy in vivo with good safety at the testing dose.

物理化学性质&存储条件

分子量	392.59
分子式	C25H36N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8-(cyclohexylmethyl)-7-(((S)-1-methylpyrrolidin-2-yl)methyl)-2-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

参考文献

1. Ge Y, et al. Acta Pharm Sin B. 2022 Aug;12(8):3326-3340.

GQ262 (GQ-262)

生物&药学活性

物理化学性质&存储条件

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GQ262 (GQ-262)

生物&药学活性

物理化学性质&存储条件

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