GPX4 inhibitor A16

Chemical Structure : GPX4 inhibitor A16

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货号: PC-21713Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

GPX4 inhibitor A16 is a potent, selective and covalent inhibitor of glutathione peroxidase 4 (GPX4), shows potent anti-proliferation activity the pancreatic cancer cell line AsPC-1 with IC50 of 22 nM.
GPX4 inhibitor A16 exhibits superior selectivity and potency compared to established representative GPX4 inhibitors, ML210 and ML162.
GPX4 inhibitor A16 exhibits excellent target selectivity and sensitivity across various pancreatic cancer cell lines.
GPX4 inhibitor A16 exerts its cell toxicity through a GPX4-targeting ferroptosis pathway.
GPX4 inhibitor A16 possesses moderate antitumor activity and demonstrates favorable safety under in vivo conditions.

物理化学性质&存储条件

分子量	471.59
分子式	C26H21N3O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((4-(Benzo[d]thiazol-2-yl)phenyl)(prop-2-yn-1-yl)amino)methyl)-N-ethynyl-N-methylbenzenesulfonamide

参考文献

1. Zifeng Tang, et al. J Med Chem. 2024 Jan 24. doi: 10.1021/acs.jmedchem.3c01608.