GPX4 inhibitor 24

Chemical Structure : GPX4 inhibitor 24

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货号: PC-20267Not For Human Use, Lab Use Only.

GPX4 inhibitor 24 is a potent glutathione peroxidase 4 (GPX4) inhibitor, induces ferroptosis in vivo.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GPX4 inhibitor 24 is a potent glutathione peroxidase 4 (GPX4) inhibitor with cell viability EC50 of 117 nM in HT1080 (GPX4 dependent) cell, induces ferroptosis.
GPX4 inhibitor 24 (100 and 200 mg/kg) engages kidney GPX4 and induces PD markers in Scid/beige mice.
GPX4 inhibitor 24 is a potentially useful tool compound for in vivo POC studies.

物理化学性质&存储条件

分子量	460.93
分子式	C22H21ClN2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-(methylsulfonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

参考文献

1. Randolph JT, et al. J Med Chem. 2023 Mar 6. doi: 10.1021/acs.jmedchem.2c01415.