GPS192 | CLK inhibitor | Probechem Biochemicals

Chemical Structure : GPS192

加入收藏

GPS192 (GPS 192)

货号: PC-20474Not For Human Use, Lab Use Only.

GPS192 (GPS 167) is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GPS192 (GPS 167) is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.
GPS192 promotes the dephoshorylation of SRSF10 and changes its interaction with partner proteins.
GPS192 treatment leads to a partial dephosphorylation of SRSF10 and increases the recovery of CLK1 and CLK4.
GPS192 impairs the growth of cancer cell line, elicits p53-dependent cytotoxicity.

物理化学性质&存储条件

分子量	392.46
分子式	C18H12N6OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1H-indazol-5-yl)amino)-N-(benzo[d]thiazol-6-yl)thiazole-4-carboxamide

参考文献

1. Muhammad Sohail, et al. NAR Cancer. 2021 May 25;3(2):zcab019.

GPS192 (GPS 192)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GPS192 (GPS 192)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.