GPS167 | CLK inhibitor | Probechem Biochemicals

Chemical Structure : GPS167

CAS No.: 3034312-19-8

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GPS167 (GPS 167)

货号: PC-73373Not For Human Use, Lab Use Only.

GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.

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2 mg	￥1880	In stock
5 mg	￥2880	In stock
10 mg	￥4580	In stock
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100 mg		Get quote

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生物&药学活性

GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.
GPS167 promotes the dephoshorylation of SRSF10 and changes its interaction with partner proteins.
GPS167 treatment leads to a partial dephosphorylation of SRSF10 and increases the recovery of CLK1 and CLK4.
GPS167 impairs the growth of cancer cell line, elicits p53-dependent cytotoxicity.
GPS167 is cytotoxic for human colorectal cancer organoids but not normal organoids.

物理化学性质&存储条件

分子量	335.385
分子式	C17H13N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1H-indazol-5-yl)-2-(phenylamino)thiazole-4-carboxamide

参考文献

1. Muhammad Sohail, et al. NAR Cancer. 2021 May 25;3(2):zcab019.

GPS167 (GPS 167)

生物&药学活性

物理化学性质&存储条件

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GPS167 (GPS 167)

生物&药学活性

物理化学性质&存储条件

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