GPR84 antagonist 837 | GPR84 antagonist | Probechem Biochemicals

Chemical Structure : GPR84 antagonist 837

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GPR84 antagonist 837 (Compound 837)

货号: PC-72357Not For Human Use, Lab Use Only.

Compound 837 (GPR84 antagonist) is a highly potent (affinity, 1 nM), selective antagonist of both orthosteric and allosteric activators of GPR84.

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生物&药学活性

Compound 837 (GPR84 antagonist) is a highly potent (affinity, 1 nM), selective antagonist of both orthosteric and allosteric activators of GPR84.
Compound 837 is able to fully block activation of human GPR84 promoted by each of 2-HTP and 6-OAU in [35S]GTPγS binding assays.
Compound 837also fully reversed activation of human GPR84 produced by 3,3′-diindolylmethane (DIM), also forskolin-amplified cAMP levels produced by both 2-HTP and 6-OAU.

物理化学性质&存储条件

分子量	422.488
分子式	C26H22N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((5,6-Bis(4-methoxyphenyl)-1,2,4-triazin-3-yl)methyl)-1H-indole

参考文献

1. Laura Jenkins, eta l. ACS Pharmacol Transl Sci. 2021 Sep 7;4(5):1598-1613.

GPR84 antagonist 837 (Compound 837)

生物&药学活性

物理化学性质&存储条件

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GPR84 antagonist 837 (Compound 837)

生物&药学活性

物理化学性质&存储条件

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