GPR54 antagonist 15a

Chemical Structure : GPR54 antagonist 15a

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货号: PC-21175Not For Human Use, Lab Use Only.

GPR54 antagonist 15a is a potent, selective, small molecule antagonist of GPR54 with IC50 of 3.6/15 nM (human/rat GPR54) in receptor binding assays.

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100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

GPR54 antagonist 15a is a potent, selective, small molecule antagonist of GPR54 with IC50 of 3.6/15 nM (human/rat GPR54) in receptor binding assays.
GPR54 antagonist 15a exhibits fully potent antagonist activity (IC50=0.93 μM) in cellular Ca2+ mobilization assays.
GPR54 antagonist 15a (0.22 mg/kg, i.v.) suppressed the plasma luteinizing hormone (LH) level in castrated male rats.

物理化学性质&存储条件

分子量	519.96
分子式	C27H23ClFN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-Cyano-6-(4-fluoro-2-hydroxyphenyl)-4-(3-piperazin-1-ylphenyl)pyridin-2-yl]furan-2-carboxamide hydrochloride

参考文献

1. Kobayashi T, et al. Bioorg Med Chem. 2010 Jul 15;18(14):5157-71.