GPR52 antagonist E7 | GPR52 antagonist | Probechem Biochemicals

Chemical Structure : GPR52 antagonist E7

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GPR52 antagonist E7 (AD31E7)

货号: PC-72129Not For Human Use, Lab Use Only.

GPR52 antagonist E7 is a novel Gpr52 antagonist, shows significant inhibitory effect on WO-459 (100 nM)-induced cAMP elevation in HEK293/GPR52 cells with IC50 of 12.0 uM.

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生物&药学活性

GPR52 antagonist E7 is a novel Gpr52 antagonist, shows significant inhibitory effect on WO-459 (100 nM)-induced cAMP elevation in HEK293/GPR52 cells with IC50 of 12.0 uM.
GPR52 antagonist E7 did not block cAMP elevation induced by Gαs-coupled GPCRs, including β2AR, GCGR and GLP-1R.
GPR52 antagonist E7 reduces mutant HTT levels and rescues Huntington's disease-associated phenotypes in cellular and mouse models.
GPR52 antagonist E7 acts as an tntracellular covalent ligand of orphan receptor GPR52.

物理化学性质&存储条件

分子量	358.39
分子式	C20H22O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR,4S,6Z,11E,12aR)-11-methyl-3-methylene-2,7-dioxo-2,3,3a,4,5,9,10,12a-octahydro-7H-6,9-(metheno)furo[2,3-f][1]oxacycloundecin-4-yl (Z)-2-methylbut-2-enoate

参考文献

1. Song H, et al. Brain. 2018 Jun 1;141(6):1782-1798.

2. Ma M, et al. ACS Chem Biol. 2020 Dec 18;15(12):3275-3284.

GPR52 antagonist E7 (AD31E7)

生物&药学活性

物理化学性质&存储条件

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GPR52 antagonist E7 (AD31E7)

生物&药学活性

物理化学性质&存储条件

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