GPR52 agonist R-185

Chemical Structure : GPR52 agonist R-185

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货号: PC-26922Not For Human Use, Lab Use Only.

GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice.

物理化学性质&存储条件

分子量	461.42
分子式	C22H19F4N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(3-fluoro-5-(trifluoromethyl)phenoxy)piperidin-1-yl)-N-(pyridin-4-yl)pyrazine-2-carboxamide

参考文献

1. Haoran Li, et al. J Med Chem. 2026 May 27. doi: 10.1021/acs.jmedchem.6c00686.