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首页-小分子抑制剂&激动剂-Others-Other Targets-GPR52 agonist R-185
GPR52 agonist R-185

Chemical Structure : GPR52 agonist R-185

CAS No.: 3066783-67-0

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GPR52 agonist R-185

货号: PC-26922Not For Human Use, Lab Use Only.

GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice.

物理化学性质&存储条件

分子量 461.42
分子式 C22H19F4N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-(3-fluoro-5-(trifluoromethyl)phenoxy)piperidin-1-yl)-N-(pyridin-4-yl)pyrazine-2-carboxamide

参考文献

1. Haoran Li, et al. J Med Chem. 2026 May 27. doi: 10.1021/acs.jmedchem.6c00686.

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