GPR4 antagonist 3b |CAS:1883333-94-5 Probechem Biochemicals

Chemical Structure : GPR4 antagonist 3b

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GPR4 antagonist 3b

货号: PC-61082Not For Human Use, Lab Use Only.

GPR4 antagonist 3b is the first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM).

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100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

GPR4 antagonist 3b is the first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM).
GPR4 antagonist 3b effectively prolongs life in the mouse myocardial infarction model in vivo, and GPR4 antagonist 3b is a very effective tool for investigating the physiologic and pharmacologic roles of GPR4.

物理化学性质&存储条件

分子量	479.672
分子式	C31H37N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-8-(piperidin-1-ylmethyl)-10,11-dihydro-5H-dibenzo[b,f]azepine

参考文献

1. Fukuda H, et al. ACS Med Chem Lett. 2016 Feb 24;7(5):493-7.

2. Tobo A, et al. PLoS One. 2015 Jun 12;10(6):e0129334.