GPR40 AgoPAM AP5 |CAS:1623194-37-5 Probechem Biochemicals

Chemical Structure : GPR40 AgoPAM AP5

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GPR40 AgoPAM AP5 (AP5)

货号: PC-35510Not For Human Use, Lab Use Only.

GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).

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生物&药学活性

GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).
AP5 demonstrates excellent in vivo efficacy with a projected human dose of 7-15 mg, shows sustained glucose lowering effect in vivo.

物理化学性质&存储条件

分子量	461.533
分子式	C28H28FNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R)-3-cyclopropyl-3-((S)-2-(2-fluoro-4-(2-methoxypyridin-4-yl)phenyl)chroman-7-yl)-2-methylpropanoic acid

参考文献

1. Chen HY, et al. ACS Med Chem Lett. 2018 Jun 14;9(7):685-690.

GPR40 AgoPAM AP5 (AP5)

生物&药学活性

物理化学性质&存储条件

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GPR40 AgoPAM AP5 (AP5)

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物理化学性质&存储条件

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