GPR183 antagonist SAE-14 | GPR183 antagonist | Probechem Biochemicals

Chemical Structure : GPR183 antagonist SAE-14

CAS No.: 1241280-25-0

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GPR183 antagonist SAE-14 (SAE-14)

货号: PC-72117Not For Human Use, Lab Use Only.

GPR183 antagonist SAE-14 is a potent, selective GPR183 antagonist with IC50 of 28.5 nM, inhibits GPR183-dependent 7α,25-dihydroxycholesterol-induced calcium signaling in HL-60 cells.

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5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

GPR183 antagonist SAE-14 is a potent, selective GPR183 antagonist with IC50 of 28.5 nM, inhibits GPR183-dependent 7α,25-dihydroxycholesterol-induced calcium signaling in HL-60 cells.
GPR183 antagonist SAE-14 inhibits calcium mobilization induced by 7α,25-OHC (EC80 209 nM).
GPR183 antagonist SAE-14 reversed CCI-induced mechanical allodynia in a time-dependent manner when administered in vivo to mice.
7α,25-dihydroxycholesterol induced allodynia in mice, SAE-14 blocked the effects of 7α,25-OHC in a dose-dependent manner.

物理化学性质&存储条件

分子量	364.368
分子式	C19H19F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3,4-difluorophenyl)-N-(3-fluoro-5-morpholinophenyl)propanamide

参考文献

1. Kathryn Braden, et al. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375.

GPR183 antagonist SAE-14 (SAE-14)

生物&药学活性

物理化学性质&存储条件

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GPR183 antagonist SAE-14 (SAE-14)

生物&药学活性

物理化学性质&存储条件

参考文献

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