GPR120 agonist 4x |CAS:1628448-77-0 Probechem Biochemicals

Chemical Structure : GPR120 agonist 4x

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GPR120 agonist 4x

货号: PC-60167Not For Human Use, Lab Use Only.

GPR120 agonist 4x is a potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays.

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250 mg		Get quote

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生物&药学活性

GPR120 agonist 4x is a potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays.
GPR120 agonist 4x exhibits no significant activity against hGPR40 (EC50>5 uM), no inhibitory activity against a broad panel of receptors and ion channels.
GPR120 agonist 4x also has an EC50 of 143 nM in β-arrestin assays.
GPR120 agonist 4x demonstrates in vivo antidiabetic activity in mice.

物理化学性质&存储条件

分子量	495.82
分子式	C20H12ClF6NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-((3-(4-chloro-2-fluorophenyl)-5-(trifluoromethyl)isothiazol-4-yl)methoxy)-3,5-difluorophenyl)propanoic acid

参考文献

1. Zhang X, et al. ACS Med Chem Lett. 2017 Jul 27;8(9):947-952.