GPR119 agonist K-833

Chemical Structure : GPR119 agonist K-833

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货号: PC-25131Not For Human Use, Lab Use Only.

GPR119 agonist K-833 is a potent GPR119 agonist with EC50 of 39.8 nM (hGPR119), potentiates GPR40 full agonist AM-5262 robust GPR40-mediated effects, leading to synergistic increases in GLP-1 levels.

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GPR119 agonist K-833 is a potent GPR119 agonist with EC50 of 39.8 nM (hGPR119), potentiates GPR40 full agonist AM-5262 robust GPR40-mediated effects, leading to synergistic increases in GLP-1 levels.

物理化学性质&存储条件

分子量	640.15
分子式	C30H43ClFN5O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(3-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)propoxy)-2-fluorophenyl)-1-(3-((((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)methyl)azetidin-1-yl)ethan-1-one

参考文献

1. Moyes CR, et al. J Med Chem. 2025 Jul 24. doi: 10.1021/acs.jmedchem.5c01030.