GPER antagonist G36 | GPER antagonist | Probechem Biochemicals

Chemical Structure : GPER antagonist G36

CAS No.: 1392487-51-2

加入收藏

GPER antagonist G36 (G36, G-36)

货号: PC-60269Not For Human Use, Lab Use Only.

GPER antagonist G36 is a potent, selective, cell-permeable GPER/GPR30 antagonist that inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 with IC50 of 112 nM and 165 nM, respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg	￥4580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GPER antagonist G36 is a potent, selective, cell-permeable GPER/GPR30 antagonist that inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 with IC50 of 112 nM and 165 nM, respectively.
GPER antagonist G36 has no detectable binding activity to either ERα or ERβ.
GPER antagonist G36 inhibits estrogen- and G-1-mediated calcium mobilization as well as ERK1/2 activation, with no effect on EGF-mediated ERK1/2 activation.

物理化学性质&存储条件

分子量	412.3
分子式	C22H22BrNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(±)-(3aR,4S,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

参考文献

1. Dennis MK, et al. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):358-66.

2. Ashton AW, et al. Mol Endocrinol. 2015 Aug;29(8):1144-55.

3. Evans NJ, et al. PLoS One. 2016 Mar 21;11(3):e0152138.

GPER antagonist G36 (G36, G-36)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GPER antagonist G36 (G36, G-36)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.