GPA 512 |CAS:1808115-35-6 Probechem Biochemicals

Chemical Structure : GPA 512

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GPA 512 (GPA512;GPA-512)

货号: PC-61139Not For Human Use, Lab Use Only.

GPA512 is the orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.

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25 mg		Get quote
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250 mg		Get quote

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生物&药学活性

GPA512 is the orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.
GPA512 increases the plasma exposure of the active parent compound 20-fold compared to Galiellalactone.
GPA512 significantly reduces tumor growth in DU145 xenograft tumors.

物理化学性质&存储条件

分子量	371.448
分子式	C17H25NO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl N-acetyl-S-((2aR,2a1S,4aR,6S,7R,7aS)-2a1-hydroxy-6-methyl-1-oxodecahydroindeno[1,7-bc]furan-7-yl)-L-cysteinate

参考文献

1. Escobar Z, et al. J Med Chem. 2016 May 26;59(10):4551-62.

GPA 512 (GPA512;GPA-512)

生物&药学活性

物理化学性质&存储条件

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GPA 512 (GPA512;GPA-512)

生物&药学活性

物理化学性质&存储条件

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