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首页-小分子抑制剂&激动剂-Others-Other Targets-GO-Y078
GO-Y078

Chemical Structure : GO-Y078

CAS No.: 1217503-60-0

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GO-Y078

货号: PC-38722Not For Human Use, Lab Use Only.

GO‐Y078 is a curcumin analog that suppresses angiogenesis through the inhibition of actin stress fiber formation, inhibits human umbilical venous epithelial cells resistant to angiogenesis inhibitors (HUVEC‐R) at 0.75 uM.

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10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GO‐Y078 is a curcumin analog that suppresses angiogenesis through the inhibition of actin stress fiber formation, inhibits human umbilical venous epithelial cells resistant to angiogenesis inhibitors (HUVEC‐R) at 0.75 uM.
GO‐Y078 decreases fibronectin 1 (FN1) gene expression.
GO‐Y078 inhibits angiogenesis through other pathways besides the VEGF pathway.

物理化学性质&存储条件

分子量 400.427
分子式 C22H24O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1E,4E)-1-(4-Hydroxy-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,4-pentadiene-3-one

参考文献

1. Kazuhiro Shimazu, et al. Cancer Sci. 2018 Oct;109(10):3285-3293.

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