GO-Y030

Chemical Structure : GO-Y030

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货号: PC-28220Not For Human Use, Lab Use Only.

GO-Y030 is a curcumin analogue and STAT3 inhibitor, inhibits STAT3 DNA binding and STAT3 transcriptional activity, reduces cell viability and induces apoptosis in in breast and pancreatic cancer cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GO-Y030 is a curcumin analogue and STAT3 inhibitor, inhibits STAT3 DNA binding and STAT3 transcriptional activity, reduces cell viability and induces apoptosis in in breast and pancreatic cancer cells.
GO-Y030 is more potent than curcumin in inducing apoptosis in colorectal cancer cells, inducesPARP and/or caspase-3 cleavages.
GO-Y030 shows an improved chemopreventive effect on intestinal tumorigenesis.
GO-Y030 reduces the number of β-catenin-positive adenoma cells in Apc580D/+ mice.

物理化学性质&存储条件

分子量	474.51
分子式	C25H30O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1E,4E)-1,5-bis(3,5-bis(methoxymethoxy)phenyl)penta-1,4-dien-3-one

参考文献

1. Ohori H, et al. Mol Cancer Ther. 2006 Oct;5(10):2563-71.

2. Cen L, et al. BMC Cancer. 2009 Mar 30;9:99.

3. Hutzen B, et al. Int J Oncol. 2009 Oct;35(4):867-72.

4. Lin L, et al. Cancer Sci. 2009 Sep;100(9):1719-27.

GO-Y030

生物&药学活性

物理化学性质&存储条件

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GO-Y030

生物&药学活性

物理化学性质&存储条件

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